Your Body Makes Bioidentical Natural Progesterone Pharmaceutical Companies Make Synthetic Progesints
Natural bioidentical progesterone is the same progesterone
that your body produces. It is the identical molecule that
your body makes. Bioidentical progesterone cannot
be patented and this means that there are many competitors.
Because of the competitors, profit is minimal.
Many big pharmaceutical companies will not sell bioidentical
progesterone cream because there is not much profit. It
simply does not fit into their business model.
To get the business model to work, the pharmaceutical companies must make a patented molecule that no one else can produce. The way to make a patented molecule is to chemically modify the progesterone molecule slightly and claim that it is a novel invention. The patent will then last about 17 years, and the company can then market it and push it on unsuspecting physicians and charge a premium for it. Since the hormone is patented, no one else can sell the molecule. Many times the marketing is so good that even physicians are NOT AWARE that these chemically modified patented molecules are different from the real thing. Many physicians Mistakenly believe that Natural Bioidentical Progesterone is the same as the chemically modified brand name progestins. Even the FTC enforces a ruling that there is no difference in side effects between the two.
Synthetic brand name progestins cause Birth Defects if taken during the pregnancy. The Physician's Desk Reference and the drug company's own instructions warn of birth defects. There is even a danger of increased risk of cancer. One company is facing 9,000 law suits as of 2009 that synthetic chemical modified hormones are causing increased breast cancer. The drug company has already lost several million dollar law suits.
Natural Bioidentical Progesterone does NOT cause birth defects. In fact, natural progesterone is routinely used by Fertility Medical Doctors to prevent 1st trimester miscarriage. Natural progesterone may also be used to prevent early delivery as well.
"Pro" means for. "Gesterone" means gestation.
Progesterone is the hormone of pregnancy. Sufficient levels of progesterone are needed to keep the pregnancy. If you do not have enough progesterone, then you will lose the pregnancy. This is why the Fertility Medical Doctors use progesterone for their "test tube" babies.
Natural Progesterone does NOT cause birth defects.
The only danger of using Natural Progesterone during pregnancy is that you cannot forget to use the progesterone one day. You must use Natural Progesterone every day. If you forget to use progesterone one day, then the progesterone levels will drop and the dropping progesterone levels will cause a miscarriage.
Progesterone increases gradually throughout the entire pregnancy. During 1 day of third trimester pregnancy, a woman produces 400 mg/day of progesterone. So progesterone is relatively safe to use from 20-400 mg/day. There is a wide therapeutic range of progesterone that can be used.
What do we know about women that are pregnant many times? Women that are pregnant many times have a lower chance of breast cancer and endometrial cancer. It is thought that progesterone causes the cells to differentiate and not proliferate. So progesterone may actually be prevent breast cancer and endometrial cancer.
Here is the difference chemically between natural bioidentical progesterone and chemically modified patented synthetic progestins.
There are slight differences between the "real" thing and the synthetic "fake" thing in structure. The "fake" progestins still fit into the progestin receptor, but stimulate the receptor to do different things. The following is a list of known side effects of a progestin from a Physician's Desk Reference.
Again, artificial progestins will NOT help a hormone imbalance. Because of these alterations to the Natural Progesterone
molecule, the drug has side effects. The following is a partial list of side effects of Provera (medroxyprogesterone
acetate) from 1993 PDR (Physician's Desk Reference):
Increased risk of birth defects such as heart and limb defects if taken during the first four months of
Beagle dogs given this drug developed malignant mammary nodules. ("malignant mammary nodules" is the same as BREAST CANCER).
Discontinue this drug if there is a sudden or partial loss of vision.
This drug passes into breast milk consequences unknown.
May contribute to thrombophlebitis, pulmonary embolism, and cerebral thrombosis.
May cause fluid retention, epilepsy, migraine, asthma, cardiac or renal dysfunction.
May cause breakthrough bleeding or menstrual irregularities.
May cause or contribute to depression.
The effect of prolonged use of this drug on pituitary, ovarian, adrenal, hepatic, or uterine function is unknown.
May decrease glucose tolerance; diabetic patients must be carefully monitored.
May increase the thrombotic disorders associated with estrogens.